Pmn-15: The Role of Lifestyle Modification in Management of Overweight Infertile Women with Polycystic Ovary Syndrome

Background: Polycystic ovary syndrome (PCOS) is a complex, heterogeneous disorder of uncertain etiology, with a prevalence of up to 10% and frequently associated with obesity, with at least 50% of women with polycystic ovary syndrome demonstrating overweight or obesity defined by body mass index >25 or >30 kg/m2. The syndrome is associated with numerous morbidities, including infertility, obstetrical complications; type 2 diabetes mellitus, cardiovascular disease, and mood and eating disorders. Material and Methods: Obesity, central obesity and insulin resistance are strongly implicated in its etiology and improving these factors should be a central treatment focus. However, extreme non-surgical efforts and short-term dietary improves both metabolic and endocrine complications of PCOS as well as clinical markers such as ovulation but are associated with high rate of weight regain Results: Recent studies indicated that lifestyle modification through individualized treatment on diet, exercise, and modifying additional lifestyle factors such as psychosocial stressors and drug addictions for 24 weeks, and monthly individual or group sessions to follow up and reinforce the changes, improves psychological selfesteem, anxiety, mean depression and general health questionnaire scores and reproductive outcomes in overweight infertile women with PCOS. In a recent clinical trial lifestyle modification significantly reduced total androgen, lipid profile and waist circumference and had better pregnancy rate in comparison with clomiphene citrate and metformin treatment in overweight infertile women with PCOS Conclusion: Lifestyle modification programs with an emphasis on behavioral management and dietary and exercise interventions without rapid weight loss leads to a reduction of central fat and improved insulin sensitivity, which restores ovulation in overweight infertile women with PCOS; however, the literature on assessment of effectiveness of lifestyle modification on improving pregnancy rate and reducing miscarriage rates, gestational diabetes has been sparse and structured recommendation for enforcing components of lifestyle modification programs should be assessed in our population.